About Adaptive Profiles
Adaptive profiles must be enabled in order to:
Perform application and file control, including malware protection (AMP), and to allow intrusion rules to use service metadata.
Adaptive profiling must be enabled (its default state) as described in Configuring Adaptive Profiles for access control rules to perform application and file control, including malware protection (AMP), and for intrusion rules to use service metadata.
For passive deployments, enable adaptive profile updates to defragment and reassemble IP traffic according to the destination hosts' operating systems.
For inline deployments Cisco recommends that, instead of enabling adaptive profile updates, you configure the inline normalization preprocessor with the Normalize TCP Payload option enabled.