Cisco HyperFlex HX 225c M6 Data Sheet

Data Sheet

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Updated:May 11, 2022

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The documentation set for this product strives to use bias-free language. For the purposes of this documentation set, bias-free is defined as language that does not imply discrimination based on age, disability, gender, racial identity, ethnic identity, sexual orientation, socioeconomic status, and intersectionality. Exceptions may be present in the documentation due to language that is hardcoded in the user interfaces of the product software, language used based on RFP documentation, or language that is used by a referenced third-party product. Learn more about how Cisco is using Inclusive Language.

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Today’s applications live across a complex, multidomain world—from enterprise data centers and private and public clouds, to campus, branch, and edge locations. Cisco HyperFlex systems with AMD EPYCTM processors make it easy to modernize and simplify deployments and operations. Engineered with Cisco Unified Computing System (Cisco UCS®) technology, and managed through the Cisco Intersight cloud-operations platform, Cisco HyperFlex systems deliver flexible scale-out infrastructure that can rapidly adapt to changing business demands.

Simplicity you can build on

With hybrid and all-flash-memory storage configurations and cloud-based management, Cisco HyperFlex systems are deployed as a preintegrated cluster with a unified pool of resources that you can quickly provision, adapt, scale, and manage to efficiently power your applications and your business (Figure 1). Based on AMD EPYC processors, these systems have world-record-setting processors with up to 128 cores per node, and up to 4 TB of memory per node.

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Figure 1.            

Cisco HyperFlex systems product family

Cisco HyperFlex HX225c M6 Node family

The Cisco HyperFlex HX225c M6 Node family delivers mission-critical, high performance in a small footprint. Physically, the system is delivered as a cluster of three or more Cisco HyperFlex HX225c M6 (hybrid) or HX225c All Flash nodes. These are integrated into a single system by a pair of Cisco UCS 6300 or 6400 series fabric interconnects, creating clusters that support general-purpose deployments (HX225c M6 Node) and mission-critical high-performance environments (HX225c M6 All Flash Node).

Incorporating AMD EPYC processors and next-generation DDR4 memory, these Cisco HyperFlex HX-series nodes are excellent choices. Cloud-based management makes it easy for you to scale your cluster to support more workloads and deliver performance, efficiency, and adaptability in a 1-Rack-Unit (1RU) form factor.

Powering next-generation applications

Cisco HyperFlex HX225c M6 All Flash and hybrid nodes with AMD EPYC CPUs are excellent for a wide range of enterprise workloads, including cloud computing, Virtual Desktop Infrastructure (VDI), databases including Microsoft SQL Server, Oracle, and SAP, and server virtualization. Cisco HyperFlex Edge configurations, based on the HX225c M6 node and HX245c M6 node, are available to support Remote-Office and Branch-Office (ROBO) locations.

Features and benefits

Table 1.        Summary of features and benefits of Cisco HyperFlex HX225c M6 Node and Cisco HyperFlex HX225c M6 All Flash Node




  32 DIMM slots (16 DIMMs per CPU socket), 3200 MHZ DDR4 for up to 4 TB of capacity

AMD EPYC processors

  One or two 3 rd Gen AMD EPYC CPUs


  Easy deployment in existing edge locations
  Use of existing top-of-rack 1 Gigabit Ethernet or 10/25 Gigabit Ethernet switching networks for cluster communication
  Support for single and dual switch configurations


Rear PCIe risers

  One to three half-height PCIe risers, or
  One to two full-height PCIe risers

The server provides an internal slot for one of the following:

  Cisco 12G SAS passthrough HBA to control SAS/SATA drives
  NVMe drives are controlled directly from the CPUs.
  The HX225c M6 node has a single 1-GE management port. A modular LAN-on-motherboard (mLOM) or an Open Compute Project (OCP) 3.0 module provides up to two 100-GE ports. A connector on the front of the chassis provides KVM functionality.

Virtualization optimization

  The Cisco UCS C225 M6 server can be used either as a standalone or as part of the Cisco Unified Computing System, which unifies computing, networking, management, virtualization, and storage access into a single integrated architecture, enabling end-to-end server visibility, management, and control in both bare-metal and virtualized environments.

Cloud-based management

Cisco Intersight simplifies operations across on-premises data centers, edge sites, and public clouds.

  Use a software-as-a-service platform that bridges applications with infrastructure
  Gain instant access to clusters regardless of where they are deployed
  Correlate visibility and management across bare-metal servers, hypervisors, Kubernetes, and serverless and application components
  Transform operations with artificial intelligence to reach needed scale and velocity
  Collaborate and work smarter and faster by automating lifecycle workflows
  Support compliance and governance with extensible, open capabilities that natively integrate with third-party platforms and tools
  Proactively respond to impending issues with a recommendation engine that determines when capacity needs to be scaled


  Up to 10 SAS/SATA/NVMe drives (up to 4 of the drives can be NVMe)

Enterprise data protection

  Pointer-based snapshot capabilities
  Native snapshots for iSCSI LUNs, including a consistency group for snapshot operations, instantaneous snapshot creation, and RESTful APIs for snapshot creation and third-party backup use
  Snapshot integration with MEDITECH BridgeHead for electronic health records and databases
  Near-instant cloning
  Inline deduplication and compression
  Native replication for disaster recovery
  N:1 replication for data center clusters with fabric interconnects and more than 4 nodes, as well as a flexible retention policy for local and remote point-in-time copies
  Data-at-rest encryption using self-encrypting drives and enterprise key management integration


  Locking bezel option to protect against unauthorized access to disk drives


  Cisco HyperFlex HX Data Platform Software (software subscription, Edge license)

Product specifications

Table 2.        Common specifications for Cisco HyperFlex HX225c M6 Node and Cisco HyperFlex HX225c M6 All Flash Node

Capability / feature



One-Rack-Unit (1RU) chassis


One or two 3rd Gen AMD EPYC CPUs


32 DIMM slots (16 DIMMs per CPU socket), 3200 MHZ DDR4 for up to 4 TB of capacity

Multi-bit error protection

This server supports multi-bit error protection.


The Cisco Integrated Management Controller (Cisco IMC) provides video using the Matrox-G200e video/graphics controller:

  Integrated 2D graphics core with hardware acceleration
  Embedded DDR memory interface supports up to 512 MB of addressable memory (8 MB is allocated by default to video memory.)
  Supports display resolutions up to 1920 x 1200 16 bpp @ 60 Hz
  High-speed, integrated 24-bit RAMDAC
  Single-lane PCI-Express host interface running at Gen 1 speed

Power subsystem

Up to two of the following hot-swappable power supplies:

  1050 W (AC)
  1050 W (DC)
  1600 W (AC)
  2300 W (AC)

One power supply is mandatory; one more can be added for 1 + 1 redundancy.

Front panel

A front-panel controller provides status indications and control buttons.


This server supports the Advanced Configuration and Power Interface (ACPI) 4.0 standard.


Eight hot-swappable fans for front-to-rear cooling


The InfiniBand architecture is supported by the PCIe slots.

Expansion slots

Three half-height riser slots

  Riser 1 (controlled by CPU 1):

    One x16 PCIe Gen 4.0 slot (Cisco VIC), half-height, 3/4 length

  Riser 2 (controlled by CPU 1):

    One x8 PCIe Gen 4.0 slot, half-height, 3/4 length

  Riser 3 (controlled by CPU 1):

    One x16 PCIe Gen 4.0 slot (Cisco VIC), half-height, 3/4 length


Two full-height riser slots

  Riser 1 (controlled by CPU 1):

    One x16 PCIe Gen 4.0 slot (Cisco VIC), full-height, 3/4 length

  Riser 2 (controlled by CPU 1):

    One x16 PCIe Gen 4.0 slot (Cisco VIC), full-height, 3/4 length


Rear panel:

  One 1GBASE-T RJ-45 management port
  One RS-232 serial port (RJ45 connector)
  One DB15 VGA connector
  Two USB 3.0 port connectors
  One flexible modular LAN-on-motherboard (mLOM)/OCP 3.0 slot that can accommodate various interface cards

Front panel:

  One KVM console connector (supplies two USB 2.0 connectors, one VGA DB15 video connector, and one serial port (RS232) RJ45 connector)

Internal storage devices

Drive storage:

Drives are installed into front-panel drive bays, which provide hot-swappable access for SAS/SATA or NVMe drives. The server is orderable in two different versions:

  HX225c M6 All Flash node (HXAF225C-M6S)

    Data drives: 6 SATA SSD

    Cache drive: 1 NVMe/SAS SSD

    Logging drive: 1 SATA SSD

  HX225c M6 (hybrid) node (HX225C-M6S)

    Data drives: 6 SAS HDD

    Cache drive: 1 SATA SSD/SAS SSD

    Logging drive: 1 SATA SSD

Integrated management controller

A Baseboard Management Controller (BMC) runs Cisco Integrated Management Controller (Cisco IMC) firmware.

Depending on your settings, the controller can be accessed through the 1-GE dedicated management port or a Cisco Virtual Interface Card (VIC).

Cisco IMC manages certain components within the server, such as the Cisco 12G SAS HBA.

Storage controllers

One Cisco M6 12G SAS RAID controller or up to two Cisco 12G SAS HBAs plug into a dedicated slot.

Cisco 12G SAS HBA:

  No RAID support
  JBOD/Pass-through Mode support
  Supports up to 16 SAS/SATA internal drives
  Plugs into a dedicated slot

Modular LAN-on-motherboard (mLOM) / Open Compute Project (OCP) 3.0 slot

The dedicated mLOM/OCP 3.0 slot on the motherboard can flexibly accommodate the following cards:

  Cisco Virtual Interface Cards (VICs)
  OCP 3.0 network interface card (UCSC-O-ID10GC)

Cisco Intersight

Cisco Intersight provides server-management capabilities.

Note: Cisco UCS Manager (UCSM) support is not available for this server.

Cisco Integrated Management Controller

Requires Release 4.2(1) or later

Operating temperature

Minimum 10°C to 35°C (50°F to 95°F) with no direct sunlight (If any A10, A100, or rear HDDs are installed, the 35°C (50°F) restriction changes to 30°C (86° F).)

Maximum allowable operating temperature derated

1C/300 m (1F/547 ft) above 950 m (3117 ft)

Extended operating temperature

5°C to 40°C (41°F to 104°F) with no direct sunlight

Maximum allowable operating temperature derated 1C/175 m (1F/319 ft) above 950 m (3117 ft)

5°C to 4°5C (41°F to 113°F) with no direct sunlight

Maximum allowable operating temperature derated 1C/125 m (1F/228 ft) above 950 m (3117 ft)

System performance may be impacted when operating in the extended operating temperature range.

Operation above 40°C is limited to less than 1% of annual operating hours.

Hardware configuration limits apply to extended operating temperature range.

Nonoperating temperature

Below -40°C or above 65°C (below -40°F or above 149°F)

Maximum rate of change (operating and nonoperating)

20°C/hr (36°F/hr)

Operating relative humidity

8% to 90% and 24°C (75°F) maximum dew-point temperature, noncondensing environment

Nonoperating relative humidity

5% to 95% and 33°C (91°F) maximum dew-point temperature, noncondensing environment

Operating altitude

0 m to 3050 m {10,000 ft)

Nonoperating altitude

Below 0 m or above 12,000 m (39,370 ft)


Cisco HyperFlex HX Data Platform Software (software subscription, Edge license)

Ordering information

For a complete list of part numbers, refer to the Cisco HyperFlex HX225 M6 Edge All Flash and hybrid server nodes specification sheet.

Cisco Unified Computing Services

Cisco and our industry-leading partners deliver services that accelerate your transition to Cisco HyperFlex systems. Cisco Unified Computing Services can help you create an agile infrastructure, accelerate time-to-value, reduce costs and risks, and maintain availability during deployment and migration. After you have deployed your system, our services can help you improve performance, availability, and resiliency as your business needs evolve and help you further mitigate risk.

Cisco environmental sustainability

Information about Cisco’s environmental sustainability policies and initiatives for our products, solutions, operations, and extended operations or supply chain is provided in the “Environment Sustainability” section of Cisco’s Corporate Social Responsibility (CSR) Report.

Reference links to information about key environmental sustainability topics (mentioned in the “Environment Sustainability” section of the CSR Report) are provided in the following table:

Sustainability topic


Information on product material content laws and regulations


Information on electronic waste laws and regulations, including products, batteries, and packaging

WEEE compliance

Cisco makes the packaging data available for informational purposes only. It may not reflect the most current legal developments, and Cisco does not represent, warrant, or guarantee that it is complete, accurate, or up to date. This information is subject to change without notice.

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Document history

New or revised topic

Described in


Initial release

Spec sheet

March, 2022



Cisco HyperFlex systems with AMD EPYC processors

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