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Stop Office 365 Email Threats

Protect Microsoft Office 365 against cyber threats with Cisco Cloud Mailbox Defense.

Office 365 email security gaps leave you exposed

Malware, phishing, and other dynamic threats can go undetected, linger in cloud mailboxes, and end up costing organizations millions of dollars in time, data, and revenue. Fast, automated detection and remediation tools can mitigate the spread of email-borne threats inside your organization.


The FBI estimates that business email compromise (BEC) attacks cost $1.2 billion in annual losses.

Source : FBI IDC report 2019


Ninety percent of cyber attacks begin with an email. It is the most prevalent way to gain a foothold in a business network.

Source : Verizon Data Breach Report


The average amount lost in fraudulent transactions stemming from a BEC attack is $125,439.

Source : HIPAA Journal

Cloud Mailbox Defense for powerful email security

Cloud Mailbox Defense is powered with superior threat intelligence from the Cisco Talos threat research team. Talos provides a 24-hour view into global traffic activity, uncovers new threats, and monitors traffic trends.

Business email compromise

A business email compromise (BEC) is an email from a legitimate-looking sender or email address that tricks the recipient into sharing something confidential or valuable. The email accounts of corporate executives or wire transfer staff are often spoofed.

Cloud Mailbox Defense leverages proven Cisco Secure Email technologies to address weaknesses in Office 365 security. It blocks advanced email threats, including BEC, ransomware, phishing, spoofing, and spam. It also provides a full graphical email conversation stack that shows the entire scope of compromised messages, including inbound, outbound, and internal user-to-user messages.


Malware is intrusive software designed to damage and destroy computers and computer systems. In 2018, Gartner reported 10.52 billion malware attacks worldwide. Examples of common malware include viruses, worms, Trojan viruses, spyware, adware, and ransomware. 

Cloud Mailbox Defense auto remediates messages that contain malicious content. Because it scans and remediates internal messages as well, it can spot the lateral movement and internal malware propagation that can occur after an account takeover. With Cisco Advanced Malware Protection, it combats ransomware hidden in attachments and with Threat Grid, it defends against sandboxing.


Phishing is an attack that sends fraudulent email communications which appear to come from a reputable source. The goal of the attack is to steal sensitive data like credit card and login information. Gartner reports that 27 percent of the data breaches in 2020 involved the theft of credentials by phishing.

Cloud Mailbox Defense focuses on specific threats, often in the realm of hard-to-detect phishing. The content of every message is analyzed to identify phishing, BEC, and spam.

Get cloud email protection for Office 365

Gain a robust layer of defense against ransomware, business email compromise, phishing, and more with Cisco Cloud Mailbox Defense. Request a 30-day free trial today.


E-book: Securing Microsoft 365 email

How to protect Microsoft 365 email users against advanced threats with a supplemental security solution.

Gartner on the security landscape (PDF)

Where does Cloud Mailbox Defense fit within the Cisco Secure Email portfolio?

Data sheet: Cloud Mailbox Defense

With the shift to cloud email platforms, organizations have changed the way they address email security.