To enable service providers deploy IPv6 in their core infrastructure, multipoint generic routing encapsulation (mGRE) tunnels over IPv6 are supported. Dynamic Multipoint Virtual Private Network (DMVPN) customers may run either IPv4 or IPv6 in their local networks, so the overlay endpoints can be either IPv4 or IPv6. For an IPv6 transport endpoint, the overlay endpoint can either be an IPv4 or IPv6 private network address.
GRE has a protocol field that identifies the passenger protocol. GRE tunnels allow Intermediate System-to-Intermediate System (IS-IS) or IPv6 to be specified as a passenger protocol, which allows both IS-IS and IPv6 traffic to run over the same tunnel. If GRE did not have a protocol field, it would be impossible to distinguish whether the tunnel was carrying IS-IS or IPv6 packets. The GRE protocol field is why it is desirable that you tunnel IS-IS and IPv6 inside GRE.